Journal: Translational Oncology
Article Title: Aurintricarboxylic acid, an inhibitor of cystathionine γ-lyase, enhances the sensitivity of chemotherapy drugs in TNBC
doi: 10.1016/j.tranon.2025.102602
Figure Lengend Snippet: The expression of CSE is negatively related to the sensitivity of chemotherapy drug in TNBC cells. (A and B) Relative expression of CSE protein in human TNBC cell lines was significantly higher compared to Hs578bst cells. ** P < 0.01. (C) mRNA level of CSE in human TNBC cell lines was significantly elevated compared to Hs578bst cells. **P<0.01. (D and E) MDA-MB-231 and BT549 cells with different levels of CSE exhibited varying sensitivities to DDP/PTX treatment. (F and G) Relative expression of P-gp protein in human TNBC cell lines was significantly higher compared to Hs578bst cells. * P < 0.05. MDA-MB-231, MDA-MB-468, BT549 were the human TNBC cell lines; Hs578bst represents normal mammary epithelial cells. All data are presented as mean ± SD ( n = 3).
Article Snippet: Human TNBC cell lines MDA-MB-231, MDA-MB-468, and human normal breast epithelial cell line Hs578Bst were purchased from the ATCC (Manassas, VA, USA).
Techniques: Expressing